COVID-19

Monitoramento

Notícias

Geral

R Verity, LC Okell, I Dorigatti et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infectious Diseases, 30-03-2020; published online. https://doi.org/10.1016/S1473-3099(20)30243-7. PDF

Bauchner H, Fontanarosa PB. Randomized Clinical Trials and COVID-19: Managing Expectations [published online ahead of print, 2020 May 4]. JAMA. 2020;10.1001/jama.2020.8115. doi:10.1001/jama.2020.8115

Cloroquina e hidroxicloroquina

ydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

O estudo francês que deu origem a toda euforia pela cloroquina, hidroxicloroquina e azitromicina.

Gautret P, Lagier J-C, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents. Published online March 2020:105949. doi: 10.1016/j.ijantimicag.2020.105949.

Tem esses dois estudos chineses que saíram antes do francês:

Gao J, Tian Z, Yang X. Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends 2020;14:72-3. doi: 10.5582/bst.2020.0104732074550.

Chen Z, Hu J, Zhang Z, et al. Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial. Version 2. medRxiv 2020.03.22.20040758. [Preprint.] doi: 10.1101/2020.03.22.20040758.

O artigo de Luis Correia criticando a metodologia do estudo francês logo depois dele ser publicado:

Luis Correia. Hidroxicloroquina: o dia em que a ciência parou. Blog Medicina Baseada em Evidências. Publicado em 20 de Março de 2020. Acessado em 14 de Maio de 2020. Disponível em: http://medicinabaseadaemevidencias.blogspot.com/2020/03/hidroxicloroquina-o-dia-em-que-ciencia.html. ↩

Chloroquine and hydroxychloroquine in covid-19

Ferner RE, Aronson JK. Chloroquine and hydroxychloroquine in covid-19. BMJ. Published online April 8, 2020:m1432. doi: 10.1136/bmj.m1432. ↩ ↩2

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial

Estudo clínico feito aqui em Manaus. Muito bom apesar de nã ter feito grupo controle com pacientes sem tratamento ou em uso apenas de pacebo.

Borba MGS, Val FFA, Sampaio VS, et al. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(4):e208857. Published 2020 Apr 24. doi: 10.1001/jamanetworkopen.2020.8857.

Estudos observacionais

Grandes estudos observacionais que saíram avaliando a possível eficácia da cloroquina e derivados.

Geleris J, Sun Y, Platt J, et al. Observational study of hydroxychloroquine in hospitalized patients with covid-19. N Engl J Med. Published online May 7, 2020:NEJMoa2012410. doi: 10.1056/NEJMoa2012410.

Rosenberg ES, Dufort EM, Udo T, et al. Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with covid-19 in new york state. JAMA. Published online May 11, 2020. doi: 10.1001/jama.2020.8630.

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data

Esse estudo para mim é o mais importante em refutar o estudo francês. Os autores usam o mesmo desfecho, cura viral. E o resultado é que não há diferença na taxa de negativação após 28 dias de internação em relação ao estudo francês.

Mahévas M, Tran V-T, Roumier M, et al. Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data. BMJ. Published online May 14, 2020:m1844. doi:10.1136/bmj.m1844

Remdesivir

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

Wang Y, Zhang D, Du G, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. The Lancet. Published online April 2020:S0140673620310229. doi:10.1016/S0140-6736(20)31022-9.

Antitrombóticos

Venous thromboembolism and heparin use in COVID-19 patients: juggling between pragmatic choices, suggestions of medical societies

Porfidia A, Pola R. Venous thromboembolism and heparin use in COVID-19 patients: juggling between pragmatic choices, suggestions of medical societies [published online ahead of print, 2020 May 4]. J Thromb Thrombolysis. 2020;1‐4. doi:10.1007/s11239-020-02125-4.

Clínica

Typical radiological progression and clinical features of patients with coronavirus disease 2019

Wang M, Guo L, Chen Q, Xia G, Wang B. Typical radiological progression and clinical features of patients with coronavirus disease 2019 [published online ahead of print, 2020 May 2]. Aging (Albany NY). 2020;12:10.18632/aging.103170. doi:10.18632/aging.103170. PDF

Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic?

Serrano-Castro PJ, Estivill-Torrús G, Cabezudo-García P, et al. Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic? [published online ahead of print, 2020 Apr 16]. Influencia de la infección SARS-Cov2 sobre Enfermedades Neurodegenerativas y Neuropsiquiátricas: ¿Una pandemia demorada? [published online ahead of print, 2020 Apr 16]. Neurologia. 2020;S0213-4853(20)30067-0. doi:10.1016/j.nrl.2020.04.002.

Testes

Sethuraman N, Jeremiah SS, Ryo A. Interpreting Diagnostic Tests for SARS-CoV-2. JAMA. Published online May 06, 2020. doi:10.1001/jama.2020.8259.

Watson Jessica, Whiting Penny F, Brush John E. Interpreting a covid-19 test result BMJ 2020; 369 :m1808

Subnotificação

Nota Técnica: Estimate of underreporting of COVID-19 in Brazil by Acute Respiratory Syndrome hospitalization reports. UFMG. Publicado em 16 de Abril de 2020. Disponível em: https://www.cedeplar.ufmg.br/noticias/1234-nota-tecnica-estimate-of-underreporting-of-covid-19-in-brazil-by-acute-respiratory-syndrome-hospitalization-reports.

Política

O editorial do The Lancet criticando Bolsonaro e as ações d governo brasileiro:

The Lancet. COVID-19 in Brazil: “So what?” The Lancet. 2020;395(10235):1461. doi:10.1016/S0140-6736(20)31095-3.PDF

BCG

Hamiel U, Kozer E, Youngster I. Sars-cov-2 rates in bcg-vaccinated and unvaccinated young adults. JAMA. Published online May 13, 2020. doi:10.1001/jama.2020.8189

Sobre o autor

Olá! Eu sou Filipe Mosca, acadêmico de medicina pela Universidade de Pernambuco. Tenho um profundo interesse em ler e escrever sobre medicina baseada em evidências.

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